Find Cheapest Airlines Flying from Cusco to Santiago

Choose from 1 carriers that fly from Cusco to Santiago, including LATAM Airlines, Enjoy the cheapest tickets on this route with LATAM Airlines.
LATAM Airlines logo LATAM Airlines
Airlines are determined based on actual purchased flight tickets from Cusco to Santiago according to previous 12 months data from Trip.com.

Explore the cheapest flights from Cusco to Santiago in the next three months. Based on Trip.com's data from the latest 7 days, one-way direct flights start at AU$ 153, and round-trip direct tickets start at AU$ 434.

Displayed flight fares from Cusco to Santiago are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Cusco to Santiago Flight Details

The distance between Cusco and Santiago is approximately 2,211.1km. It takes around 2 hours 50 minutes on average to fly from Cusco to Santiago. Based on Trip.com's data travel demand peaks in July. The off-season for travel is December.

Cheapest one-way flight priceAU$ 144
Cheapest return ticket priceAU$ 314
Off-season for travelDecember
Peak season for travelJuly
Flight distance2,211.1km
Average flight time2 hours 50 minutes
Popular airlineLATAM Airlines
Flight statistics for the Cusco–Santiago route are based on aggregated booking data from Trip.com over the past 12 months.

Trip.com Price Insights on Flights from Cusco to Santiago

What is the cheapest month for one-way flights from Cusco to Santiago?

Average price of one-way flights from Cusco to Santiago purchased by Trip.com users by month over the past 12 months.

According to Trip.com's data, the cheapest month for flights from Cusco to Santiago is April, with an average price of AU$ 240. Conversely, the most expensive month is typically February, with an average price of up to AU$ 638.

AU$ 638
AU$ 439
AU$ 240
AU$ 41
  • AU$ 240
    Apr
  • AU$ 297
    May
  • AU$ 257
    Jun
  • AU$ 368
    Jul
  • AU$ 299
    Aug
  • AU$ 387
    Sep
  • AU$ 337
    Oct
  • AU$ 299
    Nov
  • AU$ 283
    Dec
  • AU$ 390
    Jan
  • AU$ 638
    Feb
  • AU$ 390
    Mar

What's the cheapest day to fly from Cusco to Santiago?

Data is based on the average flight price for each day of the week from Cusco to Santiago on Trip.com over the past 12 months.

Based on Trip.com data from the past 12 months, the cheapest day to fly from Cusco to Santiago is Wednesday, with average prices lower than on other days. Avoid Saturday, as prices are usually highest then.

AU$ 435
AU$ 365
AU$ 294
AU$ 224
    Cheapest
  • AU$ 347
    Mon
  • AU$ 360
    Tue
  • AU$ 294
    Wed
  • AU$ 319
    Thu
  • AU$ 361
    Fri
  • AU$ 435
    Sat
  • AU$ 324
    Sun

When is the cheapest day to fly from Cusco to Santiago during ANZAC Day Holiday?

Data is based on the lowest one-way fares from Cusco to Santiago during ANZAC Day Holiday, sourced from the Trip.com database over the last 3 days.

ANZAC Day Holiday runs from Apr 25 to Apr 27. The cheapest flights from Cusco to Santiago are available on Apr 26, with fares starting at AU$ 170.

AU$ 249
AU$ 210
AU$ 170
AU$ 131
    Cheapest
  • AU$ 184
    22
    Apr
  • AU$ 229
    23
  • AU$ 198
    24
  • AU$ 240
    25
  • AU$ 170
    26
  • AU$ 249
    27
  • AU$ 210
    28

Flight FAQs

  • Which airlines offer the cheapest flights from Cusco (CUZ) to Santiago (SCL)?

    Based on Trip.com data, JetSMART Airlines offers one-way fares as low as AU$ 144 on Cheapest nonstop routes (e.g. CUZ to SCL on Mon, Apr 27), while JetSMART Airlines offers Cheapest nonstop round-trips from AU$ 314 departing on Thu, Apr 23 and returning on Sat, Apr 25.
  • At the moment, you can catch a direct flight from Cusco to Santiago with the following airlines, including: LATAM Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • It takes about 2 hours 50 minutes to fly from Cusco (CUZ) to Santiago (SCL).
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Cusco to Santiago is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • Based on Trip.com data in the past 4 weeks, there is 9 flight per week flying from Cusco to Santiago. You can check the weekly schedule for popular airlines on this route below: LATAM Airlines: -/-/T/-/T/-/S -- LA2466 (14:51) LATAM Airlines: S/M/T/W/T/F/S -- LA2366 (09:37)
  • To find best deals on flights from Cusco to Santiago, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Mon, Apr 27, with one-way flights priced at just AU$ 144.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is LATAM Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Santiago travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Cusco to Santiago is December, when demand for travel is lower.
  • After crunching the numbers on our April flight calendar, it's currently cheapest to fly from Cusco to Santiago on April 23, 2026 with JetSMART, with prices starting at AU$ 135.
  • You can land at any one of the following hubs in Santiago, with Alejandro Velasco Astete International Airport to Arturo Merino Benitez International Airport (CUZ-SCL) is by far the most common option on this route: Arturo Merino Benitez International Airport (SCL).
  • The time difference between Santiago and Cusco is 1h.
  • Tickets can only be changed or cancelled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

Trip.com Airline Insights on Flights from Cusco toSantiago

Which airlines offer the cheapest nonstop flights from Cusco to Santiago?

Data is based on the average price of all nonstop flights from Cusco to Santiago on Trip.com in the past 12 months.

Based on Trip.com data from the past 12 months, JetSMART Airlines offers the cheapest nonstop flights from Cusco to Santiago, with an average price of AU$ 225.

AU$ 179
AU$ 225
AU$ 272
AU$ 319
AU$ 365
JetSMART Airlines
AU$ 225
JetSMART Airlines
avianca
AU$ 292
avianca
Sky Airline
AU$ 321
Sky Airline
LATAM Airlines
AU$ 365
LATAM Airlines

How many flights are there each day from Cusco to Santiago?

The data is based on the flight numbers for each day of the week from Cusco to Santiago within the Trip.com database over the past month.

Based on Trip.com data from the past month, the most flights from Cusco to Santiago depart on Sunday, and the fewest flights depart on Monday/Tuesday/Thursday.

9
7
4
2
Highest
4
Mon
4
Tue
7
Wed
4
Thu
8
Fri
5
Sat
9
Sun

Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

Book with no extra fees

Prices displayed in this page are all-inclusive prices (incl. taxes, fuel surcharge, regulatory fees, etc) with all fees confirmed before payment. Fees for baggage, meals, Wi-Fi, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

Trip.com displays flight cancellation and change policies for each flight ticket during the booking process, including fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.